UNIVERSITY OF PAPUA NEW GUINEA DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY DIVISION OF BASIC MEDICAL SCIENCES SCHOOL OF MEDICINE AND HEALTH SCIENCES MBBS YEAR 4 OVERVIEW OF: NEONATAL Hb, O2-TRANSPORT; JAUNDICE Give a brief description of Haemoglobin (Hb):
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چکیده
Give a brief description of Haemoglobin (Hb): Hb is made up of Four Subunits (Tetramer) held together by multiple non-covalent interactions Each subunit (Monomer) consist of: Haem (Ferro-Protoporphyrin) and Globin protein Haem consist of a Protoporphyrin IX and Ferrous ion (Fe 2 ) Globin protein folds around the Haem group forming a hydrophobic pocket that protects the Haem, which serves as the site of Oxygen binding Different types of Hb (Hb F, Hb A) are present in humans Primary structure of Globin protein is the major difference in the types of Hb; Different subunits of various types of Hb are products of different genes
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